Summary: 

In this paper, you introduce a specific phenomena (dopamine loss) that
potentially influences the progression of Parkinson disease. This work
involves understanding the disruption in normal brain activity caused
by the dysfucntional neuronal activity caused by the loss of dopamine.

You have summarized the results from previous works that have shown
that there is increased oscillatory activity compared to healthy brain
(?!) which is rythmic in behavior when there is loss of
dopamine. Understanding the rythmicity of brain activity as the
disease progresses using data from experiments in mice is the goal of
this work.

Data for this study is collected from a specific brain region
associated with motor function using awake mice . Preprocessing of the
raw spike channel signals collected from the mice as
electro-physiological recordings is needed to get the spike
train. This is done via i. spike detection and ii. spike sorting.


Specific comments are in the attached pdf.